Wayne State opens NSIC South Division play Saturday afternoon with a 1 p.m. game at Augustana University.
Both teams enter the contest with 2-2 records.
Last weekend, the Wildcats dropped a heartbreaker to Minnesota Duluth in double overtime 34-31 while the Vikings fell at St. Cloud State 26-14.
Augustana leads the all-time series against WSC 10-8-1 and has won the last three meetings, including 44-31 in Wayne last year.
WSC won in Sioux Falls 10-7 in the 2013 season for the last Wildcat win in the series.